Vitamins & minerals · INGREDIENT PROFILE
Vitamin B12
Research topics: Nutrient status · Neurological function · Energy metabolism
Also searched as: vitamin B12, cobalamin, methylcobalamin, cyanocobalamin. Names and formulations are not necessarily interchangeable.
01 / MATCH THE FORMULA
The details to pin down.
Ingredient identity & form
Identify the cobalamin form and route. Oral, sublingual, and injected interventions must be distinguished.
Dose, duration & study fit
Micrograms, route, duration, baseline status, dietary pattern, and absorption context.
Record the tested dose from the original study. A study dose is not a recommended dose or proof that every claim at that dose is supported.
02 / READ IN CONTEXT
What changes the interpretation?
Ask whether the study addresses deficiency correction or an extra benefit in people with adequate B12 status.
- Population: Does the study population match your intended audience?
- Comparison: What changed compared with the control group—not just compared with baseline?
- Consistency: Do independent studies agree? Include null findings, limitations, and adverse events.
- Claim wording: Does the measured outcome support the strength and scope of the proposed claim?
03 / FOLLOW THE SOURCES
Research to explore.
A selected index of randomized trials and research reviews. Open the source to verify methods, results, corrections, and applicability.
2026 · Randomized Controlled Trial
Effect of Vitamin B12 Supplementation on Hematological and Athropometric Parameters in Children With Severe Acute Malnutrition, Aged 1 to 60 Months in Nutritional Rehabilitation Center (RCT). ↗
PMID 41566649 · DOI 10.1177/00099228251415045
2026 · systematic-review
Vitamin B<sub>12</sub> supplementation for anaemia, vitamin B<sub>12</sub> status, and health outcomes in women of reproductive age. ↗
PMID 42100907 · DOI 10.1002/14651858.cd016233 · PMC record available
2026 · Systematic Review · systematic-review
Maternal vitamin B12, vitamin D, and folic acid status during pregnancy and child neurodevelopment: a systematic review. ↗
PMID 42359342 · DOI 10.3389/fnins.2026.1825297 · PMC record available
2026 · Systematic Review · review-article · Network Meta-Analysis
Nutritional supplements and cognition in healthy aging and mild cognitive impairment patients: a systematic review and network meta-analysis. ↗
PMID 41764841 · DOI 10.1016/j.tjpad.2026.100518 · PMC record available
How these references were selected
First four Europe PMC relevance-ranked MED records matching the recorded ingredient/outcome query and randomized-trial, systematic-review or meta-analysis publication types. No favorable-result filter. Bibliographic discovery only; not a full-text review or exhaustive bibliography.
Captured 2026-10-08: 4 records shown from 348 matching index records. Index counts describe this query, not supporting studies or evidence quality.
(TITLE_ABS:"vitamin B12") AND (TITLE_ABS:"supplementation") AND SRC:MED AND (PUB_TYPE:"Randomized Controlled Trial" OR PUB_TYPE:"Systematic Review" OR PUB_TYPE:"Meta-Analysis")Run the recorded index search ↗04 / GO DEEPER
Guidance & source databases.
NIH ODS: Vitamin B12↗Database links open a fresh search. Registry entries can identify ongoing or unpublished trials; registration alone is not evidence of benefit.
Educational research navigation. Not individual medical advice, a safety clearance, regulatory approval, or a complete review of this ingredient. Bibliographic snapshot: 2026-10-08.