Other ingredients · INGREDIENT PROFILE
Melatonin
Research topics: Sleep timing · Sleep onset
Also searched as: melatonin. Names and formulations are not necessarily interchangeable.
01 / MATCH THE FORMULA
The details to pin down.
Ingredient identity & form
Record immediate or extended release and the delivery format.
Dose, duration & study fit
Milligrams, timing relative to bedtime, release profile, duration, and age.
Record the tested dose from the original study. A study dose is not a recommended dose or proof that every claim at that dose is supported.
02 / READ IN CONTEXT
What changes the interpretation?
Distinguish sleep onset, sleep duration, and circadian timing outcomes; check the specific population and timing protocol.
- Population: Does the study population match your intended audience?
- Comparison: What changed compared with the control group—not just compared with baseline?
- Consistency: Do independent studies agree? Include null findings, limitations, and adverse events.
- Claim wording: Does the measured outcome support the strength and scope of the proposed claim?
03 / FOLLOW THE SOURCES
Research to explore.
A selected index of randomized trials and research reviews. Open the source to verify methods, results, corrections, and applicability.
2026 · Meta-Analysis
Safety and Efficacy of Melatonin for Sleep Disorders in Cancer: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. ↗
PMID 42708337 · DOI 10.2174/0127724328470308260825053321
2026 · Meta-Analysis · Systematic Review · review-article
Sleep-Wake Disturbances in Pediatric Traumatic Brain Injury: A Systematic Review and Meta-Analysis of Interventions. ↗
PMID 42768896 · DOI 10.1002/brb3.71556 · PMC record available
2026 · Randomized Controlled Trial
The Effect of Melatonin on Sleep Quality, Anxiety, and Depression in Patients with Primary Breast Cancer Undergoing Adjuvant Chemotherapy Type: A Randomized, Double-Blind, Placebo-Controlled Trial. ↗
PMID 42533530 · DOI 10.1080/07357907.2025.2563202
2026 · Systematic Review · Review · Network Meta-Analysis
Comparative effectiveness and safety of pharmacological interventions for sleep outcomes in chronic non-cancer pain: a systematic review and network meta-analysis. ↗
PMID 42430948 · DOI 10.1016/j.smrv.2026.102340
How these references were selected
First four Europe PMC relevance-ranked MED records matching the recorded ingredient/outcome query and randomized-trial, systematic-review or meta-analysis publication types. No favorable-result filter. Bibliographic discovery only; not a full-text review or exhaustive bibliography.
Captured 2026-10-08: 4 records shown from 824 matching index records. Index counts describe this query, not supporting studies or evidence quality.
(TITLE_ABS:"melatonin") AND (TITLE_ABS:"sleep") AND SRC:MED AND (PUB_TYPE:"Randomized Controlled Trial" OR PUB_TYPE:"Systematic Review" OR PUB_TYPE:"Meta-Analysis")Run the recorded index search ↗04 / GO DEEPER
Guidance & source databases.
NCCIH: Melatonin↗Database links open a fresh search. Registry entries can identify ongoing or unpublished trials; registration alone is not evidence of benefit.
Educational research navigation. Not individual medical advice, a safety clearance, regulatory approval, or a complete review of this ingredient. Bibliographic snapshot: 2026-10-08.